Early Stage Research
Through our 60 bed Phase 1 research unit in Salt Lake City, Utah Lifetree offers high-quality expertise and experience in the conduct of early stage studies involving the measurements of pharmacodynamic parameters.
Our Phase 1 team has performed more than 100 clinical studies, including First-in-Human (FIH) studies for biologics, reformulations and new chemical entities. In addition to measuring safety and pharmacokinetic parameters, we can provide expert advice on selecting the most appropriate pharmacodynamic evaluations for your compound.
Accurate and well-interpreted pharmacodynamic data can expedite the subsequent evaluation of investigational drugs. By delivering science-driven solutions to phase I safety and pharmacologic questions, Lifetree can help facilitate more confident decisions to accelerate product development.
- First in Human and First in Patient, Single Ascending Dose / Maximum Tolerated Dose
- Multiple Ascending Dose
- Full PK/PD collections in plasma, urine, and CSF
- Safety/tolerability, optimal dosing schedules and MTD in target populations
- Cardiac Safety (QTc) evaluations
- Abuse Liability Studies
- Drug-Drug Interactions
- Bioavailability/Bioequivalence Studies
- Dose Proportionality Studies
